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Microbiology Objective Questions { Antibody }



1. The class of immunoglobulins which can cross the placenta is
A.IgM
B.IgG
C.IgA
D.IgD
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2. Self reactive antibodies are not found in significant concentration in normal serum because
A.it is impossible to generate a self-reactive antibody
B.self reactive B cells are killed by CD8 T cells
C.B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
D.self reactive B cells switch to IgA which is all secreted and not present in serum
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3.  Simulation of which of the following will lead to appearance of first antibody to appear following stimulation by an antigen?
A.IgM
B.IgA
C.IgE
D.IgG
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4. Antigen binding sites of an immunoglobulin are located in
A.light chain alone
B.heavy chain alone
C.Fc region of the antibody
D.Fab regions of the antibody
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5. Which of the following mediates Type I hypersensitivity reaction?
A.IgE
B.IgG
C.IgM
D.IgD
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6. Which of the following theory of antibody production is most widely accepted?
A.Side chain theory
B.Clonal selection theory
C.Direct template theory
D.Indirect template theory
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7. Which is the most efficient complement fixing class of antibody?
A.IgE
B.IgA
C.IgM
D.IgG
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